![]() The major area of application is the profiling of cancer-relevant tissues-including the proteomes of colorectal cancer and prostate cancer, as well as the subtyping of lymphoma and breast cancer patients. Following these advances, proteomic approaches have been used to address multiple clinical questions in the context of various cancer types. The maturation of the technology together with the development of suitable methods for quantification of human tissue proteomes has opened new doors for employing proteomics in medical applications and is shaping the growing field of clinical proteomics. Similar to the clinical goals of genomics and transcriptomics to provide a deeper understanding of a certain disease that goes beyond the standard clinical parameters of cancer diagnosis, proteomics offers a comprehensive view of the molecular players in a cell at a particular moment and in a specific state. Obtaining highly accurate quantitative proteomes on a genome-wide scale is becoming feasible within realistic measurement times. High-resolution mass spectrometry-based proteomics, aided by computational sciences, is continuously pushing the boundaries of systems biology.
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